Thermostable proteins : structural stability and design

The Resource Thermostable proteins : structural stability and design
Label
Thermostable proteins : structural stability and design
Title remainder
structural stability and design
Statement of responsibility
[edited by] Srikanta Sen, Lennart Nilsson
Contributor
Subject
Language
eng
Summary
"Thermostable Proteins: Structural Stability and Design provides a comprehensive, updated account of the physical basis of enhanced stability of thermophilic proteins and the design of tailor-made thermostable proteins, paving the way for their possible industrial applications. This book is devoted to understanding the survival mechanisms of "thermophilic life forms" at the molecular level with an emphasis on design strategies. The review chapters presented in Thermostable Proteins span a wide range of protein thermostability research. Basic structural, thermodynamic, and kinetic principles are explained and molecular strategies for the adaptation to high temperatures are delineated. In addition, this book covers: computing and simulation methods in current and future thermostability research, especially in nonempirical situations, how rigidity theory is used to improve the thermal adaptation of mesophiles Subtilisin-like serine proteases and their significant engineering applications. The state of knowledge concerning structure function relations and the origins of their structural stability. Computational and experimental approaches for the design of proteins with increased thermal stability based on sequences or three-dimensional structures. Understanding the molecular basis of how thermostable and hyperthermostable proteins gain and maintain their stability and biological function at high temperatures remains an important scientific challenge. A more detailed knowledge of protein stability not only deepens our understanding of protein structure but also helps in obtaining insights into processes that drive protein activities folding, unfolding, and misfolding essential to biological function"--Provided by publisher
Member of
Cataloging source
EBLCP
Dewey number
  • 572.6
  • 612/.01575
Illustrations
illustrations
Index
no index present
LC call number
QR84.8 S76 2011
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QU 55.9
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