Identification of TEF cofactor(s) in skeletal muscles utilizing yeast two hybrid system
Resource Information
The work Identification of TEF cofactor(s) in skeletal muscles utilizing yeast two hybrid system represents a distinct intellectual or artistic creation found in University of Missouri Libraries. This resource is a combination of several types including: Work, Language Material, Books.
The Resource
Identification of TEF cofactor(s) in skeletal muscles utilizing yeast two hybrid system
Resource Information
The work Identification of TEF cofactor(s) in skeletal muscles utilizing yeast two hybrid system represents a distinct intellectual or artistic creation found in University of Missouri Libraries. This resource is a combination of several types including: Work, Language Material, Books.
- Label
- Identification of TEF cofactor(s) in skeletal muscles utilizing yeast two hybrid system
- Statement of responsibility
- by Aijing Zhang
- Language
- eng
- Summary
- In mouse adult skeletal muscle, Ý-myosin heavy chain (ÝMyHC) gene is primarily expressed in type I slow muscle fibers. However, its expression is down-regulated when the muscle is subjected to non-weight bearing (NWB). The ÝMyHC proximal promoter (Ý293: -293bp to +120bp) has been demonstrated to possess the full activity of the endogenous promoter throughout developmental stages, as well as responsiveness to mechanical overload (MOV) in transgenic studies. Distal muscle CAT element (dMCAT), proximal MCAT (pMCAT) and ÝA/T-rich elements have all been shown to be recognized by TEF-1 (Transcriptional Enhancer Factor-1) proteins, thus demonstrating TEF plays an important role in muscle-specific gene expression and as well as muscle plasticity. There are four members in TEF transcription factor family. Although they recognize the same DNA element, observations suggest that the functions of TEF-1 proteins are not redundant. The unique "squelching" property of TEF-1 in transfection analysis suggests that transactivation activity of TEF-1 requires other limiting and titratable proteins. Protein interactions serve as important mechanisms in transcriptional regulation. It is proposed that the transcriptional specificity of TEF-1 proteins is achieved through the association with different interacting proteins. In this study, utilizing yeast two hybrid screening we obtained two unique clones encoding proteins with known interaction with TEF proteins. The results not only demonstrate the validity of yeast two hybrid experiment in our system setting, but also shed lights on the regulation of TEF-1 transactivation activity
- Additional physical form
- Also issued on the Internet.
- Cataloging source
- MMU
- Degree
- M.S.
- Dissertation year
- 2004.
- Government publication
- government publication of a state province territory dependency etc
- Granting institution
- University of Missouri--Columbia
- Illustrations
- illustrations
- Index
- no index present
- Literary form
- non fiction
- Nature of contents
-
- theses
- bibliography
Context
Context of Identification of TEF cofactor(s) in skeletal muscles utilizing yeast two hybrid systemWork of
No resources found
No enriched resources found
Embed
Settings
Select options that apply then copy and paste the RDF/HTML data fragment to include in your application
Embed this data in a secure (HTTPS) page:
Layout options:
Include data citation:
<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.library.missouri.edu/resource/aRb1fw5YUOs/" typeof="CreativeWork http://bibfra.me/vocab/lite/Work"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.library.missouri.edu/resource/aRb1fw5YUOs/">Identification of TEF cofactor(s) in skeletal muscles utilizing yeast two hybrid system</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.library.missouri.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.library.missouri.edu/">University of Missouri Libraries</a></span></span></span></span></div>
Note: Adjust the width and height settings defined in the RDF/HTML code fragment to best match your requirements
Preview
Cite Data - Experimental
Data Citation of the Work Identification of TEF cofactor(s) in skeletal muscles utilizing yeast two hybrid system
Copy and paste the following RDF/HTML data fragment to cite this resource
<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.library.missouri.edu/resource/aRb1fw5YUOs/" typeof="CreativeWork http://bibfra.me/vocab/lite/Work"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.library.missouri.edu/resource/aRb1fw5YUOs/">Identification of TEF cofactor(s) in skeletal muscles utilizing yeast two hybrid system</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.library.missouri.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.library.missouri.edu/">University of Missouri Libraries</a></span></span></span></span></div>